- Shashikant R. Pattan
- Sanjay B. Bhawar
- Santosh B. Dighe
- Mayur S. Bhosale
- Vishal B. Tambe
- Vinayak M. Gaware
- Mangesh B. Hole
- Sapana M. Nagare
- Jiban Debnath
- Supriya Mana
- Deepak S. Musmade
- Manisha S. Kedar
- Smita K. Parjane
- Priyanka P. Gadhave
- Manjusha S. Sanap
- Abhijeet N. Merekar
- Deepak K. Thakur
- Pratik V. Patel
- H. V. Shinde
- Ravindra B. Saudagar
- Ramesh S. Kalkotwar
- D. A. Jain
- Sunil A. Nirmal
- Prerana A. Chavan
- Nilesh Jadhao
- Vipul V. Dhasade
- Shruti G. Dake
- Madhuri U. Shelar
- Vinayak Gaware
- Pankaj Shinde
- Harshali Anap
- Sanjay Bhawar
- V. D. Pujar
- S. N. Hiremath
- R. B. Laware
- S. G. Jadhav
- Medha A. Khade
- Anand A. Bukitagar
- Snehlata K. Tambe
- S. V. Hiremath
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Dighe, Nachiket S.
- Rocky Mountain Fever: A Review
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka-Rahata, Dist-Ahmednagar 413736, (MS), IN
2 Department Of Medicinal Chemistry, Pravara Rural College Of Pharmacy, Pravaranagar, M.S., IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
4 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
5 Department Of Medicinal Chemistry, Pravara Rural College Of Pharmacy,Pravaranagar, M.S., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 104-110Abstract
Rocky Mountain spotted fever (RMSF) is a disease caused by the bacterium Rickettsia rickettsii which is spread to humans by ticks. Symptoms include the sudden onset of fever, headache and muscle pain followed by the development of a rash. In the laboratory, rickettsiae cannot be cultivated on agar plates or in broth, but only in viable eukaryotic host cells. Rocky Mountain spotted fever and Mediterranean spotted fever are rickettsial infections primarily of endothelial cells that normally have a potent anticoagulant function. As a result of endothelial cell infection and injury, the hemostatic system is perturbed and shows changes that vary widely from a minor reduction in the platelet count to severe coagulopathies, such as deep venous thrombosis and disseminated intravascular coagulation. Animals probably become infected by aerosol and by the bite of any of the 40 species of ticks that carry the organisms. From the portal of entry in the skin, rickettsiae spread via the bloodstream to infect the endothelium and sometimes the vascular smooth muscle cells, brain, lungs, heart, kidneys, liver, gastrointestinal tract and other organs. Rickettsia species enter their target cells, multiply by binary fission in the cytosol and damage heavily parasitized cells directly. The target cells are macrophages in the lungs, liver, bone marrow, spleen, heart valves and other organs. Clinico-epidemiologic diagnosis is ultimately a matter of suspicion. Empirical treatment and later laboratory confirmation gives specific diagnosis. Some laboratories are able to identify rickettsiae by immunohistology in skin biopsies as a timely, acute diagnostic procedure, but to establish the diagnosis; physicians usually rely on serologic demonstration of the development of antibodies to rickettsial antigens in serum collected after the patient has recovered. Currently, assays that demonstrate antibodies to rickettsial antigens themselves are preferable to the nonspecific, insensitive Weil-Felix test that is based on the crossreactive antigens of OX-19 and OX-2 strains. Tetracycline, Doxycycline and chloramphenicol are the drugs of choice for treatment. Control of the tick population on the property, keeping pets tick-free are some measures to control the disease.Keywords
Black Measles, Chloramphenicol, Rickettsia, Tetracycline.References
- Helmick CG, Bernard KW, D'Angelo LJ. Rocky Mountain spotted fever: clinical, laboratory and epidemiological features of 262 cases. J Infect Dis. 1984 Oct;150(4):480-482.
- Kirkland KB, Marcom PK, Sexton DJ, Dumler JS, Walker DH. Rocky Mountain spotted fever complicated by gangrene: report of six cases and review. Clin Infect Dis. 1993 May; 16(5):629-34.
- Centers for Disease Control and Prevention. Rocky Mountain spotted fever web site.
- Sexton DJ, Corey GR. Rocky Mountain "spotless" and "almost spotless" fever: a wolf in sheep's clothing. Clin Infect Dis. 1992 Sep; 15(3):439-48. Abstract
- Lee N, Ip M, Wong B, et al. Risk factors associated with lifethreatening rickettsial infections. Am J Trop Med Hyg 2008 Jun; 78(6):973-8. Abstract
- Chapman AS, Bakken JS, Folk SM, et al. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses and anaplasmosis - United States. MMWR. 2006 Mar 31; 55(RR04); 1-27.
- CDC. Rocky Mountain spotted fever. Prevention and Control.
- Adal KA, Cockerell CJ, Petri WA: Cat scratch disease, bacillary angiomatosis, and other infections due to Rochalimaea. N Engl J Med, 1994, 330:1509-1515.
- Drancourt M, Mainardi JL, Brouqui P, et al. Bartonella (Rochalimaea) quintana endocarditis in three homeless men. N Engl J Med , 1995,332:419-423
- Fishbein DB, Dawson JE, Robinson LE: Human ehrlichiosis in the United States, 1985 to 1990. Ann Int Med, 1994, 120:736-743.
- Ricketts HT. A micro-organism which apparently has a specific relationship to Rocky Mountain spotted fever. JAMA 1909;52:379-380
- Hechemy KE, Paretsky D and Walker DH, Mallavia (eds): Rickettsiology: Current Issues and Perspectives. NY Acad Sci, New York, 1990, Vol 590, 124-132.
- Kaplowitz LG, Fischer JJ, Sparling PF: Rocky Mountain spotted fever: a clinical dilemma. Curr Clin Top Infect Dis, , 1981 2:89-90.
- Marrie TJ: Q Fever,The Disease. CRC Press, Boca Raton, FL. 1990 McDade JE. Newhouse VF: Natural history of Rickettsia rickettsii. Annu Rev Microbiol, 1986 40:287
- McDade JE, Shepard CC, Redus MA, et al. Evidence of Rickettsia prowazekii infections in the United States. Am J Trop Med Hyg, 1981, 29:277-279.
- Moulder JW (ed): Intracellular Parasitism. CRC Press, Boca Raton, FL, 1989, 165-169.
- Walker DH (ed): Biology of Rickettsial Disease. Vols I and II. CRC Press, Boca Raton, FL, 1988, 245-248.
- Williams WJ, Radulovic S, Dasch GA, et al. Clin Infec Dis , 1994,19:93-99
- Kirk JL, Fine DP, Sexton DJ, Muchmore HG. Rocky Mountain spotted fever: a clinical review based on 48 confirmed cases, 1994, 199-203.
- Williams WJ, Radulovic S, Dasch GA, et al. Clin Infec Dis,1994,19:93-99.
- Wolbach SB, Todd JL, Palfrey FW: Etiology and Pathology of Typhus, 2002, 235-239.
- The League of Red Cross Societies Harvard Press, Cambridge, Mass, 1922
- Audy JR (ed): Red Mites and Typhus. University Press, New York, 1968, 285-290.
- Bakken JS, Dumler JS, Chen S-M, et al. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 272:212-218, 199
- Brouqui P, Dumler JS, Raoult D: Immunohistologic demonstration of Coxiella burnetii in the valves of patients with Q fever endocarditis. Am J Med,1994, 97:451-453
- Rowland LP. Bacterial infections. In: Merritt's Textbook of Neurology.8th ed. Philadelphia: Lea and Febiger, 1989:78-80
- Miller JQ, Price TR. Involvement of the brain in Rocky Mountain spotted fever. South Med J 1972; 65:437-439.
- Hornay LF, Walker DH. Meningoencephalitis as a major manifestation of Rocky Mountain spotted fever. South Med J 1988; 81:915-918.
- Von Lichtenberg F. Viral, chlamydia, rickettsial and bacterial diseases. In: Cotran RS, Kumar V, Robbins SL, eds. Robbins'Pathologic Basis of Disease. Philadelphia: Saunders, 1989:330-333.
- Benhammou B, Balafiej A, Mikou N. Mediterranean boutonneuse fever disclosed by severe neurological involvement. Arch Fr Pediatr 1991; 48:635-636.
- Brooks RG, Licitra CM, Peacock MG. Encephalitis caused by Coxiella burnetii. Ann Neurol 1986; 20:91-93.
- An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica in Mice
Authors
1 Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, IN
2 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, 413736, IN
3 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, IN
4 Department of Pharmacology, NSHM, College of Pharmaceutical Technology, Kolkata, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 31-33Abstract
In present study the anticonvulsant activity of ethanolic extract of Holarrhena antidysenterica was carried out in swiss albino mice. The anticonvulsant activity of ethanolic extract of seeds of Holarrhena antidysenterica (250 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, pentylenetetrazol (PTZ), and bicuculine (BC) test. The ethanolic extract of H. antidysenterica significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 250 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from tonic seizures induced by Pentylenetetrazol and significantly delayed the onset of tonic seizures produced by Pentylenetetrazol. The extract had no effect on bicuculine induced seizure. The ethanolic extract of H. antidysenterica (EEHA) reduced MES, PTZ induced convulsions.Keywords
Anticonvulsant, H. antidysenterica, MES, PTZ, BC.References
- Sander JWAS, Shorvon SD. Epidemiology of epilepsies. J Neurol Neurosurg Psychiatry 1996; 61: 433-43.
- Smith MC, Bleck TP. Convulsive Disorders: toxicity of anticonvulsants. Clin Neuropharmacol 1991; 14: 97-115.
- Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia 1995; 36 (2): S13-S26.
- Rajpal V. Standardisation of Botanicals (Vol-II). Eastern Publishers, The house of pharmaceuticals books, New Delhi. 2005: 196-205.
- Sukh Deb A. Selection of Prime Ayurvedic Plant Drugs 'Ancient-Modern Concordance'. Anamaya Publishers, New Delhi. 2006: 268-71.
- Nadkarni KM. The Indian Meteria Medica. Bombay Popular Prakashan. 2000: (3): 624-51.
- James AD. Handbook of Medicinal Herbs. CRC Press, 5th ed, Washington DC. 2006: 219.
- Ballal M, Srujan D, Bhat KK, et Al. Antibacterial activity of Holarrhena antidysenterica [Kurchi] against the enteric pathogen. Indian J Pharmacol 2001; 33: 392-93.
- Kavitha D, Shilpa PN, Niranjali S. Antibacterial and anti-diarrhoeal effect of alkaloids of Holarrhena antidysenterica Wall. Indian J of Exp Biol 2004; 42: 589-94.
- Mrs. Prema Veeraraghavan. Expert consultant, CPCSEA, OECD guide line No. 420; Oct 2000.
- Hegde K, Thakkar SP, Joshi AB, Shastry CS, Chandrashekar KS. Anticovusant activity of Carissa carandas Linn. Root extract in experimental mice. Trop J Pharm Res 2009; 8(2): 117-25.
- Swinyard EA, Laboratory evaluation of antiepileptic drugs. Review of Laboratory methods. Epilepsia 1969; 10: 107-19.
- Amabeoku GJ, Chikuni O. Cimetidine-induced seizures in mice. Biochem Pharmacol, 1993; 46(12): 2171-75.
- Westmoreland BF, Benarroch EE, Regan TJ, Sandok BA. Medicinal neurosciences, Rochester: Margo Foundation 1994: 307-12.
- Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology 5th ed. India: Churchill Livingstone 2005: 456-73.
- Tools for Synthesis of Natural Products:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
Source
Research Journal of Science and Technology, Vol 1, No 2 (2009), Pagination: 49-54Abstract
The present review article on tools for synthesis of natural products is to significantly facilitate organic synthesis of natural products which are of significant biological importance by the implementation of new concepts for catalysis. We focus on the recent development in natural product synthesis with the help of newer methods of organic synthesis.Keywords
Natural Products, Methods of Synthesis, Combinatorial Chemistry.- Recent Synthesis of Marine Natural Products with Anticancer Activity:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
Source
Research Journal of Science and Technology, Vol 1, No 2 (2009), Pagination: 63-70Abstract
Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.Keywords
Marine, Anti Cancer Activity, Synthesis of Dictyostatin.- Umpolung Chemistry:An Overview
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka -Rahata, Dist-Ahmednagar 413736, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 8-12Abstract
The present review article on Umpolung chemistry is to significantly facilitate organic synthesis by the implementation of new concepts for catalysis. We focus on the recent development of N- heterocyclic carbenes mediated organic reaction and its implementation to the synthesis of heterocycles of biological importance.Keywords
Umpolung, N-Heterocyclic Carbenes, Organomettalic Catalyst.- Mecaptooxadiazole a Lead Molecule in the Medicinal Chemistry: A Review
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, IN
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 4 (2011), Pagination: 93-96Abstract
Mercaptooxadiazole is a five membered heterocyclic system consists of two nitrogen and one oxygen atoms along with acidic thiol group. As it increases the acidity of the titled compounds. It can be easily synthesized from hydazides using potassium hydroxide in presence of carbon disulphide. Mercaptooxadiazoles posses wide spectrum of biological activities like antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present review is an attempt made to reveal the therapeutic and synthetic profiles of the mercaptooxadiazole ring.Keywords
Mercaptooxadiazole, Synthesis, Biological Evaluation.- An Overview of Cassia fistula:Chemistry and Pharmacological Profile
Authors
1 Pravara Rural College of Pharmacy, Loni, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/PLoni Bk. Taluka -Rahata, Dist- Ahmednagar 413736, (MS), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 143-145Abstract
Cassia fistula Linn (Leguminosae) is a shrub, extensively used in traditional medicine in tropical and warm subtropical countries. C. Fistula commonly found in waste grounds and secondary forest. The chemical constituents reported from this plant belong to different classes such as glycosides, flavonoides, steroids, mucilage and sugars. C. Fistula has number of medicinal uses, many of which have been verified by scientific methods. This review article summarizes the chemistry and pharmacological profile of C. Fistula.
Keywords
Cassia fistula, Phytochemistry, Pharmacological Activities.- A Review on Phytochemical and Pharmacological Profile of Cassia tora Linn
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/PLoni Bk.Taluka -Rahata,Dist- Ahmednagar 413736, (MS), IN
2 Pravara Rural College of Pharmacy, Pravaranagar, M.S, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 173-176Abstract
Cassia tora Linn (Leguminosae) is a shrub, extensively used in traditional medicine in tropical and warm substropical countries. C. tora commonly found in waste grounds and secondary forest. The chemical constituents reported from this plant belong to different classes such as glycosides, tannins, flavonoides, steroids, resins, mucilage and sugars. C. tora has number of medicinal uses, many of which have been verified by scientific methods. This review article summarizes the chemistry and pharmacological profile of C. tora.
Keywords
Cassia tora, Phytochemistry, Pharmacological Activity, Anthraquinone Glycoside.- Pharmacological and Synthetic Profile of 1, 2, 4-Triazoles
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, IN
2 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., IN
3 Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1807-1811Abstract
Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives.Keywords
1, 2, 4-Triazole, Pharmacological Activity, SAR, Total Synthesis.- QSAR Study and Synthesis of Some New 2, 5-Disubstituted 1, 3, 4-Oxadiazole Derivatives as Anti-Microbial and Anti-Inflammatory Agents
Authors
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni 413736, MS, IN
2 Department of Pharmacology, Pravara Rural College of Pharmacy, Loni 413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN
Source
Asian Journal of Pharmaceutical Research, Vol 4, No 4 (2014), Pagination: 174-179Abstract
The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 μcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard.Keywords
Anti-Inflammatory, Antimicrobial and Oxadiazole.- SERM’s in Treatment of Breast Cancer
Authors
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, IN
5 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 4 (2011), Pagination: 81-86Abstract
Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.Keywords
Selective Estrogen Receptor Modulators (SERM’s), Breast Cancer, Hormone Replacement Therapy (HRT).- Synthesis and Anti-Inflammatory Activity of 2-Amino Substituted Benzothiazoles
Authors
1 Pravara Rural College of Pharmacy, Loni-413736, M.S., IN
2 KLE’S College of Pharmacy, Belgaum, IN
3 College of Pharmacy, Chincholi, Nashik, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 113-115Abstract
A new series of 2-amino substituted benzothiazoles and their derivatives were prepared by multiple steps. The structures of the synthesized compounds were confirmed by Melting point, TLC, IR, and H1NMR. The compounds were screened for their anti-inflammatory activity, all the compounds shown promising anti-inflammatory activity.Keywords
2-Amino-Substituted-Benzothiazoles, Anti-Inflammatory, CHN Analysis.- Synthesis and Antidiabetic Activity of Some New Benzopyrone Derivatives
Authors
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni Bk-413736, Tal Rahata, Dist Ahmednagar, (MS), IN
2 College of Pharmacy, Chincholi, Nashik, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 126-128Abstract
A new series of benzopyrone derivatives were synthesized and the structure of these compounds was established on the basis of spectral data. The title compounds were evaluated for antidiabetic activity. Some of these compounds have shown excellent antidiabetic activity.Keywords
Benzopyrone, Antidiabetic, CHN Analysis.- Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity
Authors
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
2 Department of Pharmacology, JNMC, Belgaum, Karnataka, IN